Exemestane GH, marketed as Aromasin, is a potent steroidal aromatase inhibitor indicated for treating estrogen receptor‑positive breast cancer in postmenopausal women. It’s especially beneficial for:
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Adjuvant therapy in women who’ve completed 2–3 years of tamoxifen and are transitioning to Aromasin to complete 5 years of hormone therapy pfizermedical.comMedicines.org.uk.
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Advanced or metastatic breast cancer following failed tamoxifen therapy pfizermedical.comMedicines.org.ukGuideline Central.
Each round, off-white tablet delivers 25 mg of exemestane and is featured in convenient 30‑tablet packaging, ideal for a monthly dosing regimen pfizermedical.comMedicines.org.uk.
Directions: Take one tablet once daily after a meal, following your healthcare provider’s guidance pfizermedical.comMedscape Reference.
Why It Matters
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Unique Mechanism: Exemestane irreversibly inactivates the aromatase enzyme, leading to sustained estrogen suppression—distinct from non-steroidal options like anastrozole or letrozole Wikipedia+1.
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Proven Efficacy: Multiple clinical trials show it effectively reduces estrogen and improves outcomes for postmenopausal patients WikipediaGuideline Centralpfizermedical.com.
Important Safety Information
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Bone Health: Long-term use may reduce bone mineral density, increasing osteoporosis risk. Routine monitoring and supplementation with vitamin D and calcium may be advised pfizermedical.com.
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Drug Interactions: Concomitant use of strong CYP3A4 inducers (e.g., rifampin, phenytoin, carbamazepine) may diminish drug effectiveness and may require dosage adjustments pfizermedical.comDrugs.comRxList.
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Contraindications: Not suitable for premenopausal women (including pregnant or breastfeeding individuals) or those with known hypersensitivity pfizermedical.com+1Medicines.org.uk.
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Pharmacokinetics: The drug has a ~24-hour half-life, with absorption and metabolism influenced by food and liver/kidney function Drugs.comWikipediaRxListMedscape Reference.
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